Reconstruction of the human blood-brain barrier in vitro reveals a ...
Jun 29, 2020 · The Tsai lab examined vascular amyloid deposition with a three-dimensional model of the blood-brain barrier using endothelial cells, mural cells (pericytes and vascular smooth muscle cells), …
ALZFORUM | NETWORKING FOR A CURE
May 23, 2017 · Takahisa Kanekiyo Mayo Clinic Posted: 19 May 2017 News: Finally, a Dye to Visualize Pericyte Function Dr. Grutzendler’s group found that Nissl dye NeuroTrace 500/525 specifically …
ALZFORUM | NETWORKING FOR A CURE
Jun 21, 2019 · Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O'Farrell FM, Buchan AM, Lauritzen M, Attwell D. Capillary pericytes regulate cerebral blood flow in health and …
Pericytes Don’t Go With the Flow—They Change It - ALZFORUM
Feb 13, 2017 · Pericytes shrink and die in patients with Alzheimer’s disease, and the study supports the idea that the loss of these cells promotes the disease’s pathology. “It makes a direct link between …
Loss of Pericytes Wreaks Havoc in Mouse Brain - ALZFORUM
Feb 10, 2018 · Loss of pericytes, delicate cells that surround the smallest blood vessels in the brain, may contribute to white-matter disease, a breakdown of the myelinated neurons in the brain. That’s …
Human Blood-Brain Barrier Model Blames Pericytes for CAA
Jun 15, 2020 · Blood-brain barrier model combines human astrocytes, pericytes, and endothelial cells. APOE4 in pericytes, but not the other cells, promoted cerebral amyloid angiopathy. Blocking NFAT …
Transcriptomics Confirm Vascular Changes in Alzheimer’s Brain
Jun 22, 2023 · The thalamus (yellow), entorhinal cortex (green), and hippocampus (cyan) contain fewer endothelial cells and pericytes and more fibroblasts and ependymal cells than other brain regions. …
APPsw/0; Pdgfrβ+/- - ALZFORUM
May 2, 2014 · Pericyte proliferation, migration, and recruitment to the vascular wall is regulated by the growth factor PDGFβ, and therefore, genetic disruption of the PDGFβ receptor gene triggers …
Amyloid β oligomers constrict human capillaries in ... - ALZFORUM
Jun 22, 2019 · Second, it identifies capillary mural cells, such as pericytes, as critical for the capillary constriction. Third, it suggests that in these cells NOX4, rather than NOX2, is the source of the …
Finally, a Dye to Visualize Pericyte Function - ALZFORUM
May 23, 2017 · Pericytes—dainty little cells that decorate the brain’s smallest blood vessels— are drawing growing research interest, and controversy. For one, whether these cells help control …