Composite structure of the symmetric core of the nuclear pore complex, shown in a cartoon representation. The composite structure was generated by sequential unbiased searches for each protein subunit ...

The nuclear pore complex (NPC) is an essential, highly dynamic macromolecular assembly embedded in the nuclear envelope that orchestrates the precise exchange of proteins, RNA and other macromolecules ...

In situ model of the nuclear pore complex transport barrier: Tethered within the pore are highly dynamic protein threads termed FG Nups (green). Under physiological conditions, cargo-carrying ...

Nuclear pore complexes are more dynamic than previously thought, reshaping our understanding of a vital transport process in cells. An international study led by the University of Basel (Switzerland) ...

An international study led by the University of Basel has discovered that nuclear pore complexes—tiny gateways in the nuclear membrane—are not rigid or gel-like as once thought. Their interiors are ...

At the dawn of complex life, evolution created a container for DNA, its most treasured item. A few billion years later, 20th-century microscopists looked at this container — the nucleus — up close and ...

As warehouses go, nuclei are more like libraries than bank vaults. Too many cellular components need access to the genome to lock it down like Fort Knox. Instead, large groupings of more than 1,000 ...

Just as cities must carefully manage the flow of cars in and out of downtown, cells regulate the movement of molecules into and out of the nucleus. This microscopic metropolis relies on an intricate ...

When it comes to neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and certain forms of dementia, researchers have known that protein quality control and damage to the nuclear ...

A model of transport through the nuclear pore complex. The blue spheres represent macromolecules that do not interact with the selectively permeable barrier of the complex, while the red spheres ...

In a recent landmark study, scientists have unveiled how HIV-1 penetrates the cell's nuclear barrier—a discovery that could reshape antiviral strategies. The research, led by Professor Peijun Zhang, ...