In the mid 1980s we discovered a phosphatidylinositol kinase that co-purified with several oncoproteins and that correlated with cell transformation. When my graduate student Malcolm Whitman presented ...

Inositol phosphates are crucial secondary messengers that modulate a wide range of cellular processes, from energy metabolism to gene expression. These molecules, particularly inositol pyrophosphates, ...

The protein 'MIPS' changes its internal structure when it becomes active. Its disordered active centre becomes a defined structure with special functions. The protein plays a key role in the ...

In this common pathway, activated phospholipase C-β hydrolyzes the inositide PI 4,5-bisphosphate to release diacylglyerol and inositol 1,4,5 trisphosphate. IP3 opens specific Ca 2+ channels releasing ...