The World Health Organization (WHO) has published its new 2025 Guidelines on the replacement or removal of animal tests for the quality control of biological products.

Endotoxin testing is critical in industries such as biopharmaceuticals and medical devices to ensure product safety and reliability. Endotoxins, which are lipopolysaccharides (LPS) found in ...

The presence of harmful bacteria in parenteral drugs or implantable devices can cause inflammatory responses such as fever and, in some cases, may even be fatal. As a result, robust bacterial ...

New standards may help push more drugmakers to use a synthetic product for critical drug safety testing, instead of one made from horseshoe crab blood that has long drawn criticism. The U.S.

Every year in May when high tide coincides with the full moon, horseshoe crabs convene on the beaches of the mid-Atlantic coast to lay millions of eggs. At the same time, migratory shorebirds on their ...

As thoroughly covered in your recent article (C&EN, Oct. 28, 2024, page 26), the issue of replacing the traditional natural product test for endotoxin, limulus amoebocyte lysate (LAL), with a ...

The quality of water for pharmaceutical production (purified water, water for injection, and ultrapure water) is quantified and regulated through four parameters – total organic carbon (TOC), ...

ZURICH (Reuters) - If you've received a vaccination, hip replacement or chemotherapy without suffering toxic shock, chances are you've benefited from a vast bloodletting of horseshoe crabs. Every year ...

Charles River International Laboratories, Inc. CRL recently launched Endosafe Trillium rCR cartridges, which combine its hallmark Endosafe cartridge technology with recombinant cascade reagent (rCR).