In eukaryotes, ubiquitination is an important posttranslational process achieved through a cascade of ubiquitin-activating (E1), conjugating (E2), and ligase (E3) enzymes. Many pathogenic bacteria ...

Ethylene influences plant growth, development, and stress responses via crosstalk with other phytohormones; however, the underlying molecular mechanisms are still unclear. Here, we describe a ...

The publication reports the highly selective, DCAF16 E3 enabled degradation of BRD9 in vivo using Amphista’s proprietary, next generation Targeted Glue™ medicinal chemistry technology Amphista’s ...

Rather than neutralize disease-causing proteins by deploying small-molecule inhibitors, some developers would destroy protein targets by ushering them to the proteasome, the cell’s garbage disposal ...

SAN DIEGO, May 19, 2020 /PRNewswire/ -- Vividion Therapeutics, a biotechnology company discovering and developing highly selective small molecule medicines that drug traditionally inaccessible targets ...

WEST LAFAYETTE, Ind. — Like the plot of a mystery novel, research has found a twist in the way plants cannibalize their own cells to survive under stress. In response to drought, cold, lack of ...

Within the bustling metropolis of your cells, amidst the teeming throngs of proteins, reside the E3 ligases – the silent guardians of cellular order. These are not your average bouncers, but the ...

An illustration of Lynn McGregor. Credit: Courtesy of Lynn McGregor (McGregor); Novartis (E3 ligase); RCSB PDB (KRAS); Courtesy of Colin Garvie (protein gels) If I weren’t a chemist, I’d be: A ...

Outrun Therapeutics has launched with $10 million in seed financing. The company spun out of Satpal Virdee’s lab at the University of Dundee and is focused on stabilizing proteins, or keeping ...

SAN DIEGO--(BUSINESS WIRE)--Plexium today announced the launch of the company with the closing of a $28 million Series A financing. The financing was led by DCVC Bio and The Column Group, with ...