Xeno nucleic acids are essential for the development of nucleic acid-based drugs. To be effective, they need to be able to stably bind to natural RNA (a cellular single-stranded version of the DNA, ...

Carnegie Mellon University researchers have developed a synthetic molecule that can recognize and bind to double-stranded DNA or RNA under normal physiological conditions. The molecule could provide a ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

PicoGreen dsDNA quantitation reagent is used to quantitate double-stranded DNA and is a highly sensitive fluorescent nucleic acid stain. PicroGreen is used in a wide range of molecular biological ...

The scientist who discovered hybridization and the "other" double helix describes what it meant to biology. By Alexander Rich Fifty-two years ago I was venturing to the basement of Cal Tech chemistry ...

Research reveals key differences between single- and double-stranded RNA, insights that may prove useful to fields from agriculture to medicine. Messenger RNA, or mRNA, has been in the news recently ...