This review illustrates how the nuclear phosphoinositide-p53 signalosome integrates lipid signaling and p53 function to regulate cancer cell motility. The figure contrasts the tumor-suppressive ...

Exosome-associated THSD7A is identified as a key trigger of filopodia formation in cancer cells and neurons, revealing a ...

In this review, the authors present recent findings that uncover a previously unappreciated nuclear signaling hub: the PIPn-p53 signalosome. This complex not only modulates AKT activation within the ...

Tsukuba, Japan—Metastasis, the primary cause of cancer-related mortality, is driven by alterations in the tumor microenvironment (TME). Triple-negative breast cancer (TNBC), characterized by the lack ...

As the second leading cause of death globally, cancer is a worldwide health crisis, particularly as life expectancies continue to increase. In its final stages, cancer spreads throughout the body in a ...

Tumors are not a comfortable place to live: oxygen deficiency, nutrient scarcity, and the accumulation of sometimes harmful metabolic products constantly stress cancer cells. A research team from the ...