COPA mutations reveal alternative trigger for small intestine tumors

A signaling system known as the Wnt pathway plays a central role in how cells in the intestine grow, divide and renew ...
EurekAlert!

Coexistence of APC and KRAS mutations in familial adenomatous polyposis and endometrial cancer: A mini-review with case-based perspective

Researchers have discovered an unusual case where two well-known cancer-related mutations—APC and KRAS—coexisted in a woman with familial adenomatous polyposis (FAP) and a history of endometrial ...
News Medical

Rare coexistence of APC and KRAS mutations observed in patient with FAP and endometrial cancer

Researchers have discovered an unusual case where two well-known cancer-related mutations-APC and KRAS-coexisted in a woman with familial adenomatous polyposis (FAP) and a history of endometrial ...
Nature

Predicting colorectal cancer risk in FAP patients using patient-specific organoids

Colorectal cancer (CRC), a prevalent global cancer, is mostly sporadic. Familial adenomatous polyposis (FAP), arises from APC germline mutations. We established FAP-human embryonic stem cell lines ...
Nature

Adenomatous Polyposis Coli Role in Colorectal Cancer Dynamics

Adenomatous Polyposis Coli (APC) is a multifunctional tumour suppressor whose inactivation represents one of the earliest and most frequent events in colorectal cancer (CRC) pathogenesis. In healthy ...
EurekAlert!

Advances and challenges in targeted therapy for colorectal cancer: A focus on adenomatous polyposis coli and kirsten rat sarcoma virus mutations

APC, adenomatous polyposis coli; CBP, cAMP-response element binding protein; CIBP, calcium- and integrin-binding protein; CK, creatine kinase. CtBP, C-terminal binding protein; GRO, growth-regulated ...