A precision cancer strategy that selectively kills tumour cells while leaving healthy tissue intact may be within reach for the majority of colorectal cancer patients, according to new research ...
Researchers have identified a novel therapeutic approach for colorectal cancer by exploiting a specific genetic vulnerability found in a majority of patients.
Mitochondrial aldehyde dehydrogenase 2 (ALDH2) has been shown to protect against oxidative stress in multiple organs. ALDH2 has a role in preventing oxidative stress-induced 4-HNE adduction in ...
The WINDWARD study is a multinational, double-blind, 3-arm Phase 2 study to evaluate the safety and efficacy of mirivadelgat in adult subjects with PH-ILD. Mirivadelgat is a first-in-class oral small ...
The discovery and preclinical efficacy of ANS-858, a proprietary, selective, reversible, orally bioavailable ALDH2 inhibitor will be presented at 48 th Annual Scientific Meeting of the Research ...
Esophageal cancer is a global health problem. A new study found that alcohol dehydrogenase 2 (ADH2) and aldehyde dehydrogenase 2 (ALDH2) genotypes are associated with esophageal cancer risk in Chinese ...
Patients diagnosed with CAD using coronary angiography in our hospital were enrolled from April 2007 to December 2007. These patients had at least one coronary lesion, with luminal diametrical ...
The findings suggest that APC-deficient cells rely on ALDH2 to manage metabolic stress, making them particularly vulnerable when this pathway is disrupted. In contrast, cells with intact APC function ...
Some results have been hidden because they may be inaccessible to you
Show inaccessible results